RT Journal Article SR Electronic T1 Association of Varus Thrust With Pain and Stiffness and Activities of Daily Living in Patients With Medial Knee Osteoarthritis JF Physical Therapy JO Phys Ther FD American Physical Therapy Association SP 167 OP 175 DO 10.2522/ptj.20140441 VO 96 IS 2 A1 Fukutani, Naoto A1 Iijima, Hirotaka A1 Fukumoto, Takahiko A1 Uritani, Daisuke A1 Kaneda, Eishi A1 Ota, Kazuo A1 Aoyama, Tomoki A1 Tsuboyama, Tadao A1 Matsuda, Shuichi YR 2016 UL http://jcore-reference.highwire.org/content/96/2/167.abstract AB Background Increasing evidence highlights potential associations between varus thrust and health domains associated with knee osteoarthritis (OA).Objective The aim of this study was to investigate the association between varus thrust and 2 subcategories—“pain and stiffness” and “activities of daily living (ADL)”—of the Japanese Knee Osteoarthritis Measure (JKOM).Design This was a cross-sectional study.Methods In total, 296 outpatients with knee OA visiting orthopedic clinics were enrolled. The inclusion criteria were age ≥50 years, medial knee OA and Kellgren-Lawrence (K/L) grade ≥1 in one or both knees, and the ability to walk independently. Standard posterior-anterior knee radiographs were measured for varus alignment. Participants were video recorded while walking and were evaluated for the presence or absence of varus thrust. Pain and stiffness of the knee joint and ADL were evaluated using the JKOM. Multivariate regressions (outcomes: pain and stiffness and ADL; predictor variable: varus thrust) were performed.Results Varus thrust was present in 46 (16.2%) of 284 patients. Multivariate regression analyses demonstrated that varus thrust is independently associated with pain and stiffness, adjusted for age, sex, body mass index, K/L grade, and varus alignment (β=.17, P=.005). However, the association between varus thrust and ADL was not significant (β=.11, P=.058). Based on sensitivity analyses, including participants of K/L grade 1 had little influence on this analysis.Limitations Only 16.2% of participants had a varus thrust. Moreover, a cause-effect relationship between varus thrust and pain and stiffness remains unknown due to the cross-sectional design of this study.Conclusions Varus thrust was associated with pain and stiffness in patients with medial knee OA. However, the association between varus thrust and ADL did not reach significance.