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Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships

Heather H. Ross, Fabrisia Ambrosio, Randy D. Trumbower, Paul J. Reier, Andrea L. Behrman, Steven L. Wolf
DOI: 10.2522/ptj.20150063 Published 1 May 2016
Heather H. Ross
H.H. Ross, MPT, PhD, Department of Physical Therapy, College of Public Health Sciences, Brenau University, 500 Washington St SE, Gainesville, GA 30501 (USA).
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Fabrisia Ambrosio
F. Ambrosio, MPT, PhD, Departments of Physical Medicine & Rehabilitation, Physical Therapy, Orthopaedic Surgery, and Microbiology & Molecular Genetics and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Randy D. Trumbower
R.D. Trumbower, MPT, PhD, Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, Georgia.
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Paul J. Reier
P.J. Reier, PhD, Department of Neuroscience, University of Florida, Gainesville, Florida.
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Andrea L. Behrman
A.L. Behrman, PT, PhD, FAPTA, Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky.
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Steven L. Wolf
S.L. Wolf, PT, PhD, FAPTA, Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine; Department of Cell Biology, Emory University School of Medicine; and Center of Excellence in Vision and Neurocognitive Rehabilitation, Atlanta, Georgia.
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Abstract

The goal of regenerative medicine is to restore function through therapy at levels such as the gene, cell, tissue, or organ. For many disorders, however, regenerative medicine approaches in isolation may not be optimally effective. Rehabilitation is a promising adjunct therapy given the beneficial impact that physical activity and other training modalities can offer. Accordingly, “regenerative rehabilitation” is an emerging concentration of study, with the specific goal of improving positive functional outcomes by enhancing tissue restoration following injury. This article focuses on one emerging example of regenerative rehabilitation—namely, the integration of clinically based protocols with stem cell technologies following central nervous system injury. For the purposes of this review, the state of stem cell technologies for the central nervous system is summarized, and a rationale for a synergistic benefit of carefully orchestrated rehabilitation protocols in conjunction with cellular therapies is provided. An overview of practical steps to increase the involvement of physical therapy in regenerative rehabilitation research also is provided.

Footnotes

  • Dr Ross, Dr Ambrosio, Dr Behrman, and Dr Wolf provided concept/idea/project design. Dr Ross, Dr Ambrosio, Dr Trumbower, Dr Reier, and Dr Wolf provided writing. Dr Ross provided data collection and institutional liaisons. Dr Ross, Dr Trumbower, and Dr Behrman provided consultation (including review of manuscript before submission).

  • Received June 5, 2015.
  • Accepted January 27, 2016.
  • © 2016 American Physical Therapy Association
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Vol 96 Issue 5 Table of Contents
Physical Therapy: 96 (5)

Issue highlights

  • Group Versus Individual Physical Therapy for Veterans With Knee Osteoarthritis: Randomized Clinical Trial
  • What Influences Patient-Therapist Interactions in Musculoskeletal Physical Therapy? Qualitative Systematic Review and Meta-Synthesis
  • Identifying Patients With Chronic Low Back Pain Who Respond Best to Mechanical Diagnosis and Therapy: Secondary Analysis of a Randomized Controlled Trial
  • Therapeutic Exercise Training to Reduce Chronic Headache in Working Women: Design of a Randomized Controlled Trial
  • Effects of Nonpharmacological Interventions for Dizziness in Older People: Systematic Review
  • Effects of Cooling During Exercise on Thermoregulatory Responses of Men With Paraplegia
  • Cognitive Contributions to Freezing of Gait in Parkinson Disease: Implications for Physical Rehabilitation
  • Neck Pain and Proprioception Revisited Using the Proprioception Incongruence Detection Test
  • 10-m Shuttle Ride Test in Youth With Osteogenesis Imperfecta Who Use Wheelchairs: Feasibility, Reproducibility, and Physiological Responses
  • Tonic Stretch Reflex Threshold as a Measure of Ankle Plantar-Flexor Spasticity After Stroke
  • Diaphragm Pacing as a Rehabilitative Tool for Patients With Pompe Disease Who Are Ventilator-Dependent: Case Series
  • NF-κB Signaling Pathway in Controlling Intervertebral Disk Cell Response to Inflammatory and Mechanical Stressors
  • Mechanotransduction: Relevance to Physical Therapist Practice—Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces
  • Developmental Biology and Regenerative Medicine: Addressing the Vexing Problem of Persistent Muscle Atrophy in the Chronically Torn Human Rotator Cuff
  • Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships
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Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships
Heather H. Ross, Fabrisia Ambrosio, Randy D. Trumbower, Paul J. Reier, Andrea L. Behrman, Steven L. Wolf
Physical Therapy May 2016, 96 (5) 734-742; DOI: 10.2522/ptj.20150063

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Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships
Heather H. Ross, Fabrisia Ambrosio, Randy D. Trumbower, Paul J. Reier, Andrea L. Behrman, Steven L. Wolf
Physical Therapy May 2016, 96 (5) 734-742; DOI: 10.2522/ptj.20150063
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  • Article
    • Abstract
    • Stem Cells for Neural Regeneration
    • Limitations Associated With Stem Cell Therapies in the CNS
    • CNS Stem Cell Transplantation Studies
    • Building Evidence for Rehabilitation to Augment CNS Stem Cell Therapies
    • Professional Opportunities to Forward Regenerative Rehabilitation
    • Conclusions
    • Footnotes
    • References
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Show more Regenerative Rehabilitation and Genomics Special Series

Subjects

  • Special Series and Special Issues
    • Special Series on Regenerative Rehabilitation and Genomics
  • Intervention
    • Therapeutic Exercise
  • Perspectives
  • Neurology/Neuromuscular System
    • Neurology/Neuromuscular System: Other
  • Physical Therapist Practice
    • Clinical Decision Making

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