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Mechanotransduction: Relevance to Physical Therapist Practice—Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces

Sharon L. Dunn, Margaret L. Olmedo
DOI: 10.2522/ptj.20150073 Published 1 May 2016
Sharon L. Dunn
S.L. Dunn, PT, PhD, OCS, Department of Physical Therapy, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71103 (USA).
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Margaret L. Olmedo
M.L. Olmedo, MD, Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center.
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Article Information

vol. 96 no. 5 712-721
DOI 
https://doi.org/10.2522/ptj.20150073
PubMed 
26700270

Published By 
American Physical Therapy Association
Print ISSN 
0031-9023
Online ISSN 
1538-6724

History 
  • Received February 4, 2015
  • Accepted December 13, 2015
Copyright & Usage 
© 2016 American Physical Therapy Association

Author Information

  1. Sharon L. Dunn and
  2. Margaret L. Olmedo
  1. S.L. Dunn, PT, PhD, OCS, Department of Physical Therapy, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71103 (USA).
  2. M.L. Olmedo, MD, Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center.
  1. Address all correspondence to Dr Dunn at: sdunn2{at}lsuhsc.edu.
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Vol 96 Issue 5 Table of Contents
Physical Therapy: 96 (5)

Issue highlights

  • Group Versus Individual Physical Therapy for Veterans With Knee Osteoarthritis: Randomized Clinical Trial
  • What Influences Patient-Therapist Interactions in Musculoskeletal Physical Therapy? Qualitative Systematic Review and Meta-Synthesis
  • Identifying Patients With Chronic Low Back Pain Who Respond Best to Mechanical Diagnosis and Therapy: Secondary Analysis of a Randomized Controlled Trial
  • Therapeutic Exercise Training to Reduce Chronic Headache in Working Women: Design of a Randomized Controlled Trial
  • Effects of Nonpharmacological Interventions for Dizziness in Older People: Systematic Review
  • Effects of Cooling During Exercise on Thermoregulatory Responses of Men With Paraplegia
  • Cognitive Contributions to Freezing of Gait in Parkinson Disease: Implications for Physical Rehabilitation
  • Neck Pain and Proprioception Revisited Using the Proprioception Incongruence Detection Test
  • 10-m Shuttle Ride Test in Youth With Osteogenesis Imperfecta Who Use Wheelchairs: Feasibility, Reproducibility, and Physiological Responses
  • Tonic Stretch Reflex Threshold as a Measure of Ankle Plantar-Flexor Spasticity After Stroke
  • Diaphragm Pacing as a Rehabilitative Tool for Patients With Pompe Disease Who Are Ventilator-Dependent: Case Series
  • NF-κB Signaling Pathway in Controlling Intervertebral Disk Cell Response to Inflammatory and Mechanical Stressors
  • Mechanotransduction: Relevance to Physical Therapist Practice—Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces
  • Developmental Biology and Regenerative Medicine: Addressing the Vexing Problem of Persistent Muscle Atrophy in the Chronically Torn Human Rotator Cuff
  • Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships
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Mechanotransduction: Relevance to Physical Therapist Practice—Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces
Sharon L. Dunn, Margaret L. Olmedo
Physical Therapy May 2016, 96 (5) 712-721; DOI: 10.2522/ptj.20150073

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Mechanotransduction: Relevance to Physical Therapist Practice—Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces
Sharon L. Dunn, Margaret L. Olmedo
Physical Therapy May 2016, 96 (5) 712-721; DOI: 10.2522/ptj.20150073
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  • Article
    • Abstract
    • Mechanotransduction: Defined
    • Cells Known to Be Influenced by Mechanotransduction
    • Molecular Biology
    • Receptors of Mechanical Stimuli
    • Downstream Cellular Effects of Mechanical Stimulation
    • Role of the Extracellular Matrix
    • Load Responsiveness
    • Load Specificity
    • Shear and Endothelial Cells
    • Tension and Lung Tissue
    • Compression, Distraction, and Bone
    • Multiple Forces and Cartilage
    • Tension and Skeletal Muscle
    • Tension and Tendon
    • Tension and Skin
    • Importance of Physiologic Loads to Tissue Integrity in Health and Use of Precise Loads in Repair
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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Show more Regenerative Rehabilitation and Genomics Special Series

Subjects

  • Perspectives
  • Special Series and Special Issues
    • Special Series on Regenerative Rehabilitation and Genomics
  • Neurology/Neuromuscular System
    • Anatomy: Central Nervous System and Neuromuscular System
  • Musculoskeletal System/Orthopedic
    • Musculoskeletal System/Orthopedic: Other
    • Anatomy and Physiology: Musculoskeletal System

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