Figures
Brain activation in each genotype group, contrasting paretic hand movement with rest. During movement of the paretic hand, larger brain activation (measured using a significance threshold of P<.001, which is approximately Z>3 in the figure) was seen among (A) the 26 patients with stroke who lacked the brain-derived neurotrophic factor (BDNF) val66met polymorphism compared with (B) the 16 patients with stroke who had the polymorphism. This finding was particularly true in the primary sensorimotor cortex contralateral to the moving hand (indicated by yellow arrows), which, in each case, was the ipsilesional primary sensorimotor cortex. The color bar at bottom indicates significance of activation.
Tables
Participant Characteristics in Relation to Brain-Derived Neurotrophic Factor Val66Met Polymorphisma
↵a Values are mean±standard error of the mean, except for the National Institutes of Health Stroke Scale, for which values are median (interquartile range). Scores on the arm motor Fugl-Meyer scale (FM) reflect moderate-to-severe arm motor deficits (maximum score=66; higher is better). Scores on the Nottingham Sensory Assessment reflect overall mild sensory deficits (maximum score=17; higher is better). Scores on the Geriatric Depression Scale reflect overall mild depression symptoms (higher is worse; scores >10 generally consistent with depression). M=male, F=female, Y=yes, N=no, L=left, R=right.
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