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Relationship Between Lower Extremity Muscle Strength and All-Cause Mortality in Japanese Patients Undergoing Dialysis

Ryota Matsuzawa, Atsuhiko Matsunaga, Guoqin Wang, Shuhei Yamamoto, Toshiki Kutsuna, Akira Ishii, Yoshifumi Abe, Kei Yoneki, Atsushi Yoshida, Naonobu Takahira
DOI: 10.2522/ptj.20130270 Published 1 July 2014
Ryota Matsuzawa
R. Matsuzawa, MS, Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan, and Hemodialysis Center, Sagami Junkanki Clinic, Sagamihara, Japan.
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Atsuhiko Matsunaga
A. Matsunaga, PhD, Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 252-0373, Japan.
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Guoqin Wang
G. Wang, PhD, Kitasato Clinical Research Center, School of Medicine, Kitasato University.
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Shuhei Yamamoto
S. Yamamoto, PhD, Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University.
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Toshiki Kutsuna
T. Kutsuna, PhD, Rehabilitation Center, Kitasato University East Hospital, Sagamihara, Japan.
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Akira Ishii
A. Ishii, MS, Hemodialysis Center, Sagami Junkanki Clinic, and Department of Cardio-angiology, Graduate School of Medical Sciences, Kitasato University.
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Yoshifumi Abe
Y. Abe, MS, Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University.
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Kei Yoneki
K. Yoneki, MS, Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University.
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Atsushi Yoshida
A. Yoshida, MD, Hemodialysis Center, Sagami Junkanki Clinic.
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Naonobu Takahira
N. Takahira, PhD, Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University.
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Figure 1.
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Figure 1.

Flow diagram of the participant selection and exclusion process.

Figure 3.
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Figure 3.

Kaplan-Meier analysis of survival for 190 patients undergoing hemodialysis. Participants with knee extensor strength above the median value of 40% (thick dark line) at baseline had significantly better survival than those with a lower value (dotted line) (P=.003 by log-rank test).

Tables

Table 1.
Table 1.

Patient Characteristics, Lower Extremity Muscle Strength, and Physical Performance at Baselinea

  • ↵a Values are expressed as median (25th percentile, 75th percentile) or number (percentage of total).

  • b History of coronary disease, congestive heart failure, myocardial infarction, peripheral vascular disease, or other cardiac disease.

Table 2.
Table 2.

Baseline Characteristics by Knee Extensor Strength (<40% or ≥40%)a

  • ↵a Values are expressed as median (25th percentile, 75th percentile) or number (percentage of total).

  • b History of coronary disease, congestive heart failure, myocardial infarction, peripheral vascular disease, or other cardiac disease.

Table 3.
Table 3.

Univariate and Multivariate Cox Models for the Effects of Lower Extremity Muscle Strength on Survivala

  • ↵a Analyses were performed using a Cox proportional hazards regression model. HR=hazard ratio, 95% CI=95% confidence interval.

  • b Unadjusted by clinicopathological factors of survival.

  • c Adjusted by age, sex, body mass index, time on hemodialysis, comorbidity score, and levels of serum albumin and C-reactive protein.

  • d Adjusted by applying a propensity score, which is a conditional probability of knee extensor strength determined by other clinicopathological factors.

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Vol 94 Issue 7 Table of Contents
Physical Therapy: 94 (7)

Issue highlights

  • Dosing in Children With Brain Injury or Cerebral Palsy
  • Effects of Stepping Training on Nonlocomotor Skills
  • Physical Therapists' Clinical Knowledge of Multidisciplinary Low Back Pain Treatment Guidelines
  • Lower Extremity Muscle Strength and All-Cause Mortality in Japanese Patients Undergoing Dialysis
  • Muscle Weakness Poststroke
  • Clinical Identifiers for Early-Stage Primary/Idiopathic Adhesive Capsulitis
  • Hierarchical Properties of the Fugl-Meyer Assessment Scale in Acute and Chronic Stroke
  • Lower-Extremity Range-of-Motion Measurements in Children With Cerebral Palsy
  • Modified Dynamic Gait Index
  • A Simple Discharge Planning Tool Following Hospital Admission for an Isolated Lower Limb Fracture
  • Application of LSVT BIG Intervention in Parkinson Disease
  • Unilateral Vestibular Damage and the Musculoskeletal System
  • Human Movement System
  • Continuum of Care
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Relationship Between Lower Extremity Muscle Strength and All-Cause Mortality in Japanese Patients Undergoing Dialysis
Ryota Matsuzawa, Atsuhiko Matsunaga, Guoqin Wang, Shuhei Yamamoto, Toshiki Kutsuna, Akira Ishii, Yoshifumi Abe, Kei Yoneki, Atsushi Yoshida, Naonobu Takahira
Physical Therapy Jul 2014, 94 (7) 947-956; DOI: 10.2522/ptj.20130270

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Relationship Between Lower Extremity Muscle Strength and All-Cause Mortality in Japanese Patients Undergoing Dialysis
Ryota Matsuzawa, Atsuhiko Matsunaga, Guoqin Wang, Shuhei Yamamoto, Toshiki Kutsuna, Akira Ishii, Yoshifumi Abe, Kei Yoneki, Atsushi Yoshida, Naonobu Takahira
Physical Therapy Jul 2014, 94 (7) 947-956; DOI: 10.2522/ptj.20130270
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