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Task-Specific Training in Huntington Disease: A Randomized Controlled Feasibility Trial

Lori Quinn, Katy Debono, Helen Dawes, Anne Elizabeth Rosser, Andrea H. Nemeth, Hugh Rickards, Sarah J. Tabrizi, Oliver Quarrell, Iris Trender-Gerhard, Mark J. Kelson, Julia Townson, Monica Busse
DOI: 10.2522/ptj.20140123 Published 1 November 2014
Lori Quinn
L. Quinn, PT, PhD, School of Healthcare Sciences, Cardiff University, Cardiff, United Kingdom.
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Katy Debono
K. Debono, BSc AnatomicalScience(Hons), BSc Physiotherapy, MCSP, School of Healthcare Sciences, Cardiff University.
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Helen Dawes
H. Dawes, PhD, MMedSci, Movement Science Group, Oxford Brookes University, Oxford, United Kingdom.
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Anne Elizabeth Rosser
A.E. Rosser, PhD, MB, BChir, BA(Hons), Schools of Medicine and Biosciences, Cardiff University.
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Andrea H. Nemeth
A.H. Nemeth, MB, BS, DPhil, CCST, Department of Clinical Genetics, Churchill Hospital, Oxford.
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Hugh Rickards
H. Rickards, MB, ChB, MMedSci, MRCPsych, MD, FRCPsych, The Barberry Centre, Birmingham, United Kingdom.
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Sarah J. Tabrizi
S.J. Tabrizi, FRCP, PhD, FMedSci, BSc(Hons), Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom.
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Oliver Quarrell
O. Quarrell, MD, FRCP, BSc, Sheffield Children's Hospital, Sheffield, United Kingdom.
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Iris Trender-Gerhard
I. Trender-Gerhard, MD, Institute of Human Development, University of Manchester, Manchester, St Mary's Hospital/Central Manchester Foundation Trust.
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Mark J. Kelson
M.J. Kelson, PhD, MSc, BSc, South East Wales Trial Unit, Cardiff University School of Medicine.
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Julia Townson
J. Townson, BA(JointHons), South East Wales Trial Unit, Cardiff University School of Medicine.
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Monica Busse
M. Busse, PhD, MSc(Med), BSc(Med)Hons, MCSP, BSc(Physiotherapy), School of Healthcare Sciences, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff, CF14 4XN United Kingdom.
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Figure.

Task-Related Training in Huntington's Disease (TRAIN-HD) CONSORT flow diagram.

Tables

Table 1.
Table 1.

Mean (SD) [Range] Scores on Disease-Specific Measures for All Participants at Assessment 1 (Baseline), Categorized by Control Group and Intervention Groupa

  • ↵a Total functional capacity: range=0–13, higher is better; Unified Huntington's Disease Rating Scale (UHDRS) Cognitive Score: range=0–no maximum value, higher score is better; UHDRS Functional Score: range=0–25, higher score is better; UHDRS Total Motor Score: range=0–124, lower score is better; disease burden score: lower score is better.

  • b n=12.

Table 2.
Table 2.

Examples of Goals Set for 3 Different Participants in the Intervention Group Using Goal Attainment Scaling (GAS)a

  • ↵a The current level of skill attainment (determined within the first 3 intervention sessions) was set at a score of −1; the expected outcome at the end of the intervention was set at a score of 0; a somewhat better outcome than expected was set at 1; a much better outcome than expected was set at a score of 2; a worse outcome than expected was set at a score of −2. The scores at the end of the intervention were determined by the intervention therapist, either based on direct observation (all 3 examples here) or by participant interview (if self-report).

Table 3.
Table 3.

Number of Goals (n=50) Scored on Goal Attainment Scaling and Corresponding Percentagesa

  • ↵a See Table 2 for Goal Attainment Scaling scoring criteria.

Table 4.
Table 4.

Unadjusted Descriptive Statistics Split by Treatment Group for Each Outcome at Assessments 1, 2, and 3a

  • ↵a Assessment 1 was performed at baseline, assessment 2 at week 8, and assessment 3 at week 16. The ANCOVA controlled for sex, disease burden score, Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, Berg Balance Scale score, and score of variable in question at assessment 1 (complete case analysis). ANCOVA=analysis of covariance, HDQoL=Huntington's Disease Health-Related Quality of Life.

  • b Effect sizes are calculated from the adjusted treatment effect, and the standard error and sample size are calculated from the ANCOVA.

  • c n=27.

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Vol 94 Issue 11 Table of Contents
Physical Therapy: 94 (11)

Issue highlights

  • Response to Motor Control Exercises and Graded Activity for Patients With Low Back Pain
  • Task-Specific Training in Huntington Disease
  • Rehabilitation Therapies After Botulinum Toxin-A
  • Relationship Between Cumulative Lifting Load and Lumbar Disk Degeneration
  • Minimal Clinically Important Difference of the Functional Gait Index
  • Self-efficacy and Mobility With Wheelchair Use
  • KOOS-PS and KOOS Function and Sport Scores
  • Comparison of Ultrasound and Fingerbreadth Palpation Methods
  • Validation of the BESTest in Stroke
  • Valid Test for Manual Dexterity in Multiple Sclerosis
  • Introduction to the GRADE Approach
  • Theoretical Domains Framework
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Task-Specific Training in Huntington Disease: A Randomized Controlled Feasibility Trial
Lori Quinn, Katy Debono, Helen Dawes, Anne Elizabeth Rosser, Andrea H. Nemeth, Hugh Rickards, Sarah J. Tabrizi, Oliver Quarrell, Iris Trender-Gerhard, Mark J. Kelson, Julia Townson, Monica Busse
Physical Therapy Nov 2014, 94 (11) 1555-1568; DOI: 10.2522/ptj.20140123

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Task-Specific Training in Huntington Disease: A Randomized Controlled Feasibility Trial
Lori Quinn, Katy Debono, Helen Dawes, Anne Elizabeth Rosser, Andrea H. Nemeth, Hugh Rickards, Sarah J. Tabrizi, Oliver Quarrell, Iris Trender-Gerhard, Mark J. Kelson, Julia Townson, Monica Busse
Physical Therapy Nov 2014, 94 (11) 1555-1568; DOI: 10.2522/ptj.20140123
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  • Randomized Controlled Trials

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